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Factors associated with prolonged delirium: a systematic review
Monidipa Dasgupta1, Loretta M Hillier
1Division of Geriatric Medicine, Department of Medicine, The Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. monidipa.dasgupta@sjhc.london.on.ca
International Psychogeriatrics
|January 23, 2010
Summary
Persistent delirium is linked to dementia, multiple medical conditions, and severe or hypoactive symptoms. Further research is needed to identify individuals at risk for prolonged delirium.
Area of Science:
- Gerontology
- Neurology
- Critical Care Medicine
Background:
- Delirium is a common complication of acute illness.
- Recovery from delirium varies among individuals.
- Factors influencing delirium persistence remain unclear.
Purpose of the Study:
- To systematically review factors associated with persistent delirium.
- To understand why some patients recover while others do not.
Main Methods:
- Conducted a systematic literature search of multiple databases.
- Included English/French studies with prospective delirium diagnosis (DSM criteria).
- Analyzed associations between prognostic variables and delirium persistence up to six months.
Main Results:
- Included 21 observational studies across various clinical settings.
- Identified patient factors (dementia, comorbidities, functional status), delirium characteristics (hypoactive symptoms, severity), and illness factors (severity, hypoxia).
- Found associations between persistence and dementia, multiple medical conditions, delirium severity, hypoactive symptoms, and hypoxic illnesses.
Conclusions:
- Preliminary factors suggest potential identification of at-risk individuals.
- More research is required to confirm predictors of persistent delirium.
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