Stereotactic body radiotherapy: a review.

Area of Science:

• Radiation Oncology
• Medical Physics
• Cancer Therapy

Background:

• Stereotactic body radiotherapy (SBRT) integrates stereotactic radiosurgery's precision with motion management for tumors and normal tissues.
• Understanding the radiobiological principles is crucial for SBRT efficacy.

Observation:

• SBRT presents unique challenges in meeting strict dosimetric requirements while managing physiological tissue movement.
• This work provides a historical overview and developmental trajectory of SBRT.

Findings:

• Published SBRT outcomes for lung, liver, pancreas, kidney, prostate, and spinal lesions are reviewed and synthesized.
• The current evidence supporting SBRT is critically evaluated.

Implications:

• Identifies key ongoing clinical trials to advance SBRT applications.
• Highlights the growing evidence base and future directions for SBRT in clinical practice.