Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 16, 2026

Alignment of Visible-Light Optical Coherence Tomography Fibergrams with Confocal Images of the Same Mouse Retina
07:02

Alignment of Visible-Light Optical Coherence Tomography Fibergrams with Confocal Images of the Same Mouse Retina

Published on: June 30, 2023

Artifacts in automatic retinal segmentation using different optical coherence tomography instruments.

Andrea Giani1, Mario Cigada, Daniel D Esmaili

  • 1G. B. Bietti Eye Foundation, IRCCS, Rome, Italy. andreagiani@gmail.com

Retina (Philadelphia, Pa.)
|January 23, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing Polypoidal Choroidal Vasculopathy-Related OCT Features in the TENAYA and LUCERNE Trials.

Ophthalmology science·2026
Same author

Tropomyosin-Related Kinase Receptor Type B Agonism in Geographic Atrophy-The Translational Challenges from Preclinical Data to a First-in-Human Trial.

Ophthalmology science·2026
Same author

Spontaneous RPE Tear Associated with Non-neovascular Fibrosis Contraction in Extensive Macular Atrophy with Pseudodrusen-like Appearance (EMAP).

Retina (Philadelphia, Pa.)·2026
Same author

Steroidome Dysregulation and Complement C4 Copy Number Variation in Men With Central Serous Chorioretinopathy.

Investigative ophthalmology & visual science·2026
Same author

Real-Time High-Resolution OCT for Imaging Retinal and Choroidal Blood Flow.

Investigative ophthalmology & visual science·2026
Same author

Optical Coherence Tomography (OCT) Features of Inactive Multifocal Choroiditis With Panuveitis and Punctate Inner Choroidopathy (MFCPU/PIC) Lesions.

American journal of ophthalmology·2026
Same journal

Persistent placoid maculopathy: long term outcomes and prognostic factors.

Retina (Philadelphia, Pa.)·2026
Same journal

ANTI-VEGF THERAPY SWITCHING RETINAL DISEASES: Characterizing Clinical Manifestations and Common Involved Genes: ERRATUM.

Retina (Philadelphia, Pa.)·2026
Same journal

THE EFFICACY AND SAFETY OF SUBRETINAL BALANCED SALT SOLUTION INJECTION IN DIABETIC MACULAR EDEMA WITH HARD EXUDATES: ERRATUM.

Retina (Philadelphia, Pa.)·2026
Same journal

EVALUATING CLINICAL OUTCOMES OF AMNIOTIC MEMBRANE COVERAGE COMBINED WITH EARLY VITRECTOMY IN THE MANAGEMENT OF PERFORATING GLOBE INJURIES.

Retina (Philadelphia, Pa.)·2026
Same journal

Mid-Phase Hyperfluorescent Plaques as a biomarker of disease activity in Central Serous Chorioretinopathy: Clinical Course and Treatment Response - MICRoN report number Ten.

Retina (Philadelphia, Pa.)·2026
Same journal

Severe retinal non-perfusion is associated with fewer retinal lesions on ultra-wide field fundus photography in proliferative diabetic retinopathy.

Retina (Philadelphia, Pa.)·2026
See all related articles

Different optical coherence tomography (OCT) instruments show varying artifact errors in retinal segmentation. Spectral-domain OCT reduces but doesn't eliminate these errors, which are more common in pathologic eyes.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Accurate retinal segmentation is crucial for diagnosing and monitoring various eye conditions.
  • Optical coherence tomography (OCT) is a key technology for in vivo imaging of retinal layers.
  • Automated segmentation algorithms aim to improve efficiency and reproducibility in OCT analysis.

Purpose of the Study:

  • To compare and evaluate artifact errors in automatic inner and outer retinal boundary detection.
  • To assess the performance of different time-domain and spectral-domain OCT instruments in retinal segmentation.
  • To identify factors influencing segmentation accuracy, such as eye pathology and device type.

Main Methods:

  • Six different OCT devices (time-domain and spectral-domain) were used to image normal and pathologic eyes.

More Related Videos

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Related Experiment Videos

Last Updated: Jun 16, 2026

Alignment of Visible-Light Optical Coherence Tomography Fibergrams with Confocal Images of the Same Mouse Retina
07:02

Alignment of Visible-Light Optical Coherence Tomography Fibergrams with Confocal Images of the Same Mouse Retina

Published on: June 30, 2023

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

  • Standard analysis protocols were applied for macular thickness evaluation.
  • Error frequencies, including percentage of examinations with errors (EF-exam) and errors per B-scan, were calculated for each instrument.

    • Main Results:

    • The overall EF-exam across all instruments was 25.8%, with normal eyes showing 6.9% and pathologic eyes 32.7%.
    • Pathologic eyes with macular holes (83.3%), epiretinal membrane with cystoid macular edema (66.6%), and neovascular AMD (50.3%) had the highest EF-exam.
    • Significant differences in EF-exam were observed among OCT instruments (P < 0.0001), with Zeiss Stratus showing the highest error rate per B-scan.

    Conclusions:

    • Spectral-domain OCT instruments demonstrate improved, though not perfect, retinal segmentation compared to older technologies.
    • Segmentation accuracy is consistently lower in pathologic eyes than in normal eyes across all tested OCT devices.
    • Differences in segmentation errors are likely due to variations in analysis algorithms, highlighting the need for manual adjustment evaluation and interoperator variability assessment.