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Association between mitral and aortic valve calcification and preferential left or right coronary artery disease

Chaim Yosefy1, Ariela Malushitsky, Jafary Jamal

  • 1Cardiology Department, Barzilai Medical Center Campus, Ben-Gurion University, Ashkelon, Israel. yosefyc@bgu.ac.il

The Journal of Heart Valve Disease
|January 27, 2010
PubMed

Insights

Coronary artery disease (CAD) localization differs with valvular calcification. Isolated left CAD links to aortic valve calcification (AVC) or combined valvular calcification (CVC), while isolated right CAD associates with mitral annular calcification (MAC) or CVC.

Area of Science:

  • Cardiology
  • Radiology
  • Biomedical Imaging

Background:

  • Mitral annular calcification (MAC) and aortic valve calcification (AVC) are established predictors of coronary artery disease (CAD).
  • Limited understanding exists regarding the relationship between the specific localization of CAD (left vs. right coronary arteries) and the presence of MAC or AVC.

Purpose of the Study:

  • To investigate the association between the side of coronary artery disease (CAD) localization and specific types of valvular calcification.
  • To determine if isolated left or right coronary artery disease correlates differently with mitral annular calcification (MAC), aortic valve calcification (AVC), or combined valvular calcification (CVC).

Main Methods:

  • A retrospective cohort analysis of 1,000 coronary angiographies in patients with established CAD.
  • Classification of CAD distribution into isolated right coronary tree disease, isolated left coronary tree disease, or both.
  • Echocardiographic review for the presence and type of valvular calcification (MAC, AVC, CVC).

Main Results:

  • Among 167 patients with isolated CAD, valvular calcification (VC) was found in 70.
  • Isolated left CAD with VC showed a higher association with AVC (32%) and CVC (53%) compared to MAC (15%).
  • Isolated right CAD with VC demonstrated a stronger association with MAC (62%) and CVC (31%) than with AVC (7%).

Conclusions:

  • Isolated left coronary artery disease is more frequently associated with aortic valve calcification (AVC) or combined valvular calcification (CVC).
  • Isolated right coronary artery disease shows a significant association with mitral annular calcification (MAC) or CVC, but rarely with AVC.
Abstract

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