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Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
Published on: May 6, 2015
[Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus]
Xiao-guang Zhang1, Kui-biao Li, Jing Ma
1Peking Union Medical College, Beijing 100730, China.
Objective:
To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.
Methods:
In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.
Results:
The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.
Conclusion:
The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.
