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Nitrones as dipoles for rapid strain-promoted 1,3-dipolar cycloadditions with cyclooctynes

Craig S McKay1, Joseph Moran, John Paul Pezacki

  • 1Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, ON, CanadaK1A 0R6.

Chemical Communications (Cambridge, England)
|January 29, 2010
PubMed
Summary

Strain-promoted cycloadditions using nitrones and cyclooctynes are significantly faster than azide-based reactions. This discovery offers a more efficient method for chemical synthesis and bioconjugation applications.

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