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[The expression of some homing and co-receptor molecules on CD4+ T cells in AIDS patients]

Yan Tan1, Ming-Xia Zhang, Ying-Xia Liu

  • 1The Third People's Hospital of Shenzhen, Shenzhen 518020, China.

Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi = Zhonghua Shiyan He Linchuang Bingduxue Zazhi = Chinese Journal of Experimental and Clinical Virology
|January 30, 2010
PubMed

Insights

In AIDS patients, CD4+ T cell function is impaired, with reduced expression of homing receptors CD49d, CCR9, CD62L, and CCR5. Highly Active Antiretroviral Therapy (HAART) partially restores this function, indicating potential use of these markers for disease progression monitoring.

Area of Science:

  • Immunology
  • Virology
  • Cell Biology

Background:

  • CD4+ T cells play a crucial role in immune response.
  • Acquired Immunodeficiency Syndrome (AIDS) significantly impairs CD4+ T cell function.
  • Understanding immune cell marker expression is vital for assessing disease progression and treatment efficacy.

Purpose of the Study:

  • To evaluate the expression of CD49d, CCR9, CD62L, and CCR5 on CD4+ T cells in AIDS patients before and after Highly Active Antiretroviral Therapy (HAART).
  • To assess the potential of these markers in indicating AIDS progression and immune reconstitution.

Main Methods:

  • Flow cytometry was used to analyze the expression of CD49d, CCR9, CD62L, and CCR5 on CD4+ T cells.
  • The study included 42 AIDS patients and 18 healthy controls.
  • Expression levels were compared between pre-HAART, post-HAART, and HIV-negative groups.

Main Results:

  • AIDS patients pre-HAART showed decreased CD4+ T cell numbers and frequencies of CD4+ T cells expressing CCR9 and CCR5 compared to post-HAART.
  • Expression of CD49d, CCR9, and CD62L on CD4+ T cells was significantly lower in pre-HAART patients.
  • Post-HAART patients still exhibited lower frequencies of CD4+ T cells, CD62L+, and CCR5+ cells compared to HIV-negative controls.

Conclusions:

  • CD4+ T cell number and function are impaired in AIDS patients, evidenced by reduced expression of homing receptors (CD49d, CCR9, CD62L) and coreceptor (CCR5).
  • HAART therapy can partially reverse these pathological changes.
  • CD49d, CCR9, and CD62L expression levels may serve as indicators for AIDS progression and immune recovery following HAART.
Abstract

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