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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

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Related Experiment Video

Updated: Jun 16, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

[What's new in oncodermatology?].

M Bagot1

  • 1Service de Dermatologie, Centre de Cancérologie Cutanée et Centre de Recherche sur la Peau, Hôpital Saint Louis, Paris, France. martine.bagot@sls.aphp.fr

Annales De Dermatologie Et De Venereologie
|January 30, 2010
PubMed
Summary
This summary is machine-generated.

Epidemiologic studies reveal rising rates of melanoma and cutaneous lymphomas. Research links genetic variants, Merkel cell polyoma virus, pesticides, and steroid use to increased cancer risk.

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Apparatus for Harvesting Tissue Microcolumns
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Related Experiment Videos

Last Updated: Jun 16, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Apparatus for Harvesting Tissue Microcolumns
06:06

Apparatus for Harvesting Tissue Microcolumns

Published on: October 25, 2018

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

  • Oncology
  • Epidemiology
  • Dermatology

Context:

  • Rising incidence of melanoma and cutaneous lymphomas in the US.
  • Identification of genetic risk variants for melanoma.
  • Increased frequency and plasticity of tumor stem cells.

Purpose:

  • To review recent findings on risk factors and treatments for melanoma and lymphomas.
  • To explore the role of viruses, environmental exposures, and therapies.
  • To discuss advancements in targeted melanoma treatments.

Summary:

  • Epidemiologic data show increasing melanoma and lymphoma rates, with identified genetic risk factors.
  • Merkel cell polyoma virus is ubiquitous in skin, more frequent in sun-exposed and immunocompromised individuals.
  • Pesticide exposure and prolonged topical steroid use are linked to lymphoma development.
  • Alpha interferon adjuvant therapy shows potential in specific melanoma subgroups (ulcerated primaries).
  • Targeted therapies (c-kit, BRAF inhibitors) offer new hope for advanced melanoma.

Impact:

  • Highlights crucial environmental and therapeutic factors influencing skin cancer risk.
  • Informs public health strategies for cancer prevention and early detection.
  • Guides clinical practice regarding steroid use and adjuvant therapies.
  • Advances understanding of viral oncogenesis in skin cancers.
  • Promotes development of precision medicine for melanoma treatment.