Stress, ROS, and actin--a volatile menage à trois?

In the analysis of structural systems, it is common to encounter members subjected to various forces and couple moments. Simplifying these systems can make the analysis more manageable and easier to understand. One approach to achieve this simplification is by moving a force to a point O that does not lie on its line of action and adding a couple with a moment equal to the moment of the force about point O.
The principle of transmissibility plays a crucial role in this process. According to...

Jealousy is an instinctive yet socially complex emotion that arises when a close relationship is threatened. Its origins lie in both biological imperatives and sociocultural conditioning, making it a multifaceted psychological construct. Although universally experienced, the triggers and expressions of jealousy vary notably between individuals, especially across genders, due to evolutionary pressures and cultural influences.Gender Differences and Evolutionary TheoryEvolutionary theory explains...

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a direction parallel to...

Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a direction parallel to...

Actin filaments (F-actin) are composed of actin subunits. The dissociation of actin monomers can occur from either end of F-actin. The rate of dissociation is faster from the minus-end or the pointed end, where the actin subunits exist with a bound ADP, together known as ADP-actin. The depolymerization of F-actin is aided by proteins, including the actin-depolymerizing factor (ADF) and cofilin family of proteins, gelsolin, and glia maturation factor (GMF).
In F-actin, the ADF/cofilin proteins...

The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...