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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Updated: Jun 16, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Staphylococcus aureus osteomyelitis in Hawaii.

Guliz Erdem1, Raymond Salazar, Chieko Kimata

  • 1Department of Pediatrics, University of Hawaii, Honolulu, HI 96826, USA. guliz@hawaii.edu

Clinical Pediatrics
|February 2, 2010
PubMed
Summary
This summary is machine-generated.

In Hawaii, methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis patients experienced more complications than those with methicillin-susceptible Staphylococcus aureus (MSSA). However, most patients had MSSA infections, with higher MRSA rates in Pacific Islander and Native Hawaiian populations.

Related Experiment Videos

Last Updated: Jun 16, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Public Health

Background:

  • Osteomyelitis is a bone infection.
  • Staphylococcus aureus is a common cause of osteomyelitis.
  • Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA) are two types of Staphylococcus aureus.

Purpose of the Study:

  • To investigate the clinical and laboratory findings and outcomes of MRSA and MSSA osteomyelitis in Hawaii.
  • To compare the characteristics of MRSA and MSSA osteomyelitis patients.

Main Methods:

  • Retrospective chart review of 62 culture-proven osteomyelitis patients from 1996 to 2007.
  • Analysis of patient demographics, clinical findings, laboratory results, and treatment outcomes.

Main Results:

  • 15 patients (24%) had MRSA osteomyelitis, and 47 patients (76%) had MSSA osteomyelitis.
  • MRSA patients had higher peak erythrocyte sedimentation rate and C-reactive protein values.
  • MRSA patients experienced a higher rate of systemic complications and more frequent surgical procedures.

Conclusions:

  • The majority of osteomyelitis cases in Hawaii were caused by MSSA, unlike other staphylococcal infections.
  • Pacific Islander and Native Hawaiian ethnicities were disproportionately affected by MRSA osteomyelitis.
  • MRSA osteomyelitis is associated with increased complications and surgical interventions.