Use of aripiprazole in clozapine induced enuresis: report of two cases
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Published on: February 4, 2014
1Department of Psychiatry, Incheon Christian Hospital, Incheon, Korea.
Abstract:
This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.
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