Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Route of Allergen Immunotherapy: A Global Look Into Physicians' Motivations.

Allergy·2026
Same author

Drug-induced anaphylaxis in pregnant women: a call for correct labeling antibiotic allergies.

Current opinion in allergy and clinical immunology·2026
Same author

Anaphylaxis and Epinephrine Use in Pregnancy.

The journal of allergy and clinical immunology. In practice·2026
Same author

Association Between Domestic Mold Detection and Clinical Outcomes in House Dust Mite Allergic Patients.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2026
Same author

Allergic rhinitis activity and efficacy of 300 IR house dust mite sublingual immunotherapy tablet in pediatrics.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Management and Immunotherapy for Fungal Allergy: Clinical Practice and Unmet Needs.

Clinical reviews in allergy & immunology·2026
Same journal

[Advances and perspectives in vascularized composite allotransplantation preservation].

Bulletin de l'Academie nationale de medecine·2025
Same journal

[COVID-19: Neurological manifestations and complications during the acute phase of the disease].

Bulletin de l'Academie nationale de medecine·2024
Same journal

[Role of psychological factors in post-COVID-19 condition].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[From the origin of Sars-CoV-2 to dangerous virology/biology].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[Neurological forms of long COVID in adults: Critical approach].

Bulletin de l'Academie nationale de medecine·2023
Same journal

[Post-COVID-19 syndrome].

Bulletin de l'Academie nationale de medecine·2023
See all related articles

Related Experiment Video

Updated: Jun 16, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

[Allergen-specific immunotherapy or desensitization].

Pascal Demoly1, François-Bernard Michel

  • 1Unité d'Exploration des Allergies, Maladies Respiratoires, Hôpital Arnaud de Villeneuve, CHU de Montpellier et Inserm U657, 34295 Montpellier Cedex 5, France. pascal.demoly@inserm.fr

Bulletin De L'Academie Nationale De Medecine
|February 3, 2010
PubMed
Summary
This summary is machine-generated.

Allergen-specific immunotherapy (ASIT) offers an etiological treatment for allergic respiratory diseases like asthma and rhinoconjunctivitis. Its increasing use is supported by improved extracts, understanding of mechanisms, and new formulations, benefiting patients unresponsive to standard treatments.

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Related Experiment Videos

Last Updated: Jun 16, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Area of Science:

  • Immunology
  • Allergology
  • Respiratory Medicine

Context:

  • Allergen-specific immunotherapy (ASIT) has evolved significantly since its inception in 1911.
  • Early skepticism has been replaced by evidence-based acceptance due to robust clinical trials.
  • Current advancements include improved allergen extracts, enhanced understanding of mechanisms, and novel administration routes.

Purpose:

  • To review the current status and future directions of allergen-specific immunotherapy for respiratory allergies.
  • To highlight the factors contributing to the increasing adoption of ASIT.
  • To identify areas requiring further research for optimizing ASIT efficacy and application.

Summary:

  • ASIT is an etiological treatment for allergic rhinoconjunctivitis and asthma, demonstrating efficacy in double-blind placebo-controlled studies.
  • Factors driving its increased use include better allergen extracts, mechanistic insights, oral tablet forms, and rationalized prescribing.
  • It provides a valuable option for severe cases unresponsive to or intolerant of pharmacological treatments.

Impact:

  • ASIT offers a disease-modifying treatment option for allergic respiratory conditions.
  • Further research is crucial for refining patient selection, treatment duration, and dosing schedules.
  • Well-designed trials focusing on patient-important outcomes are needed to solidify its role in managing allergic diseases.