Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Thromboinflammation and hemostatic activation drive early mortality risk in pulmonary embolism.

Research and practice in thrombosis and haemostasis·2026

Same author

Enoxaparin, Tinzaparin, and Apixaban Modulate Cancer Cell Procoagulant Activity and Viability: Comparison with Quercetin.

Cancers·2026

Same author

A Comparative Study of Porcine and Ovine Derived Defibrotide: Coagulation Profiles, Molecular Characteristics, and DNA Content.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026

Same author

Circulating Exosomal MicroRNAs as Potential Biomarkers for Pulmonary Embolism.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·2026

Same author

Multifactorial thrombotic risk in Evans syndrome: a case report and review of the literature.

Thrombosis journal·2026

Same author

Venous thromboembolism in patients with multiple myeloma treated with B-cell maturation antigen-directed chimeric antigen receptor T-cell therapy: A systematic review.

British journal of haematology·2026

Same journal

A Brief Overview of Colitis Cystica Profunda and Potential Animal Models.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

Same journal

Collaboration between Human and Veterinary Research and Medical Experts Could Provide a Balanced Discussion on the Ethics of Using Animals in Research.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

Same journal

Analysis of IVC Microenvironments During an Extended Cage-Change Interval in Rats (Rattus norvegicus).

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

Same journal

Letter to the Editor: Contemporary Concerns Regarding Laboratory Animal Feed.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

Same journal

Machine Learning in Nonhuman Primate Models of Infectious Diseases: Current Applications and Future Perspectives.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

Same journal

Performance Validated 8-Week Sanitation Interval for Mouse (Mus musculus) Wire-Bar Lids: ATP and CFU Outcomes.

Journal of the American Association for Laboratory Animal Science : JAALAS·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 16, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Coagulation profiling of random-source cats.

Elizabeth McGeehan¹, Karen Wielgus, Lee Cera

¹Department of Comparative Medicine, Loyola University Medical Center, Maywood, Illinois, USA. emcgeehan@lumc.edu

Journal of the American Association for Laboratory Animal Science : JAALAS

|February 4, 2010

Summary

This summary is machine-generated.

Class B vendor cats show significant variations in coagulation and antiprotease activities, potentially impacting their suitability for cardiovascular research. These findings highlight the need for careful consideration of feline health status in research settings.

More Related Videos

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Related Experiment Videos

Last Updated: Jun 16, 2026

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo

Published on: August 4, 2018

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Area of Science:

Veterinary Medicine
Hematology
Comparative Physiology

Background:

Class B vendor cats (Felis catus) exhibit variable health statuses.
Hemostatic parameters and antiprotease activities can differ significantly between animal populations.
Understanding coagulation profiles is crucial for animal research subject selection.

Purpose of the Study:

To compare hemostatic parameters and antiprotease activities between Class B vendor cats and healthy control cats.
To assess the variability of coagulation factors in Class B vendor cats.
To determine the suitability of Class B vendor cats for vascular or cardiovascular research.

Main Methods:

Comparison of prothrombin time, partial thromboplastin time, common pathway assay, and thrombin time.
Measurement of antiprotease activities: anti-factor Xa (antiXa), anti-factor IIa (antiIIa), heparin cofactor II, and antithrombin.
Analysis of plasma samples using standard clotting and chromogenic substrate assays.
Statistical analysis including tests for homogeneity of variances and one-way ANOVA.

Main Results:

Significant differences were observed between groups for heparin cofactor II and Heptest activity levels.
Prothrombin time showed significant variance differences between groups, precluding ANOVA.
Class B vendor cats displayed wide variations in coagulation parameters compared to controls.

Conclusions:

Class B vendor cats exhibit substantial variability in coagulation and antiprotease activities.
The wide variations suggest Class B cats may not be optimal subjects for vascular or cardiovascular research.
Initial health status likely contributes to the observed hemostatic parameter variations in vendor cats.