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Deep vein thrombosis in acute myelogenous leukemia
Amaylia Oehadian1, Mohammad Iqbal, Rachmat Sumantri
1Departement of Internal Medicine, Padjadjaran University-dr. Hasan Sadikin Hospital, Bandung 40161, Indonesia. amaylia_oehadian@yahoo.com
Acta Medica Indonesiana
|February 4, 2010
Summary
Thrombotic complications, like deep vein thrombosis, are underrecognized in acute leukemia. This case highlights the challenges in managing thrombosis alongside bleeding risks in leukemia patients.
Area of Science:
- Hematology
- Oncology
- Vascular Medicine
Background:
- Thrombotic complications are often underestimated in acute leukemia, overshadowed by bleeding risks.
- Leukemia shares thrombogenic factors with solid tumors but possesses unique prothrombotic features.
Observation:
- A case of an 18-year-old female presenting with deep vein thrombosis (DVT) in the right leg.
- Symptoms included leg swelling, weakness, pallor, and fever, without preceding bleeding manifestations.
- Hematologic findings revealed anemia, leukocytosis with monoblasts, and thrombocytopenia.
Findings:
- Compression ultrasonography confirmed deep vein thrombosis in the right femoral and popliteal veins.
- Hyperleukocytosis, increased tissue factor expression, and therapeutic agent effects contribute to thrombosis in leukemia.
- Severe thrombocytopenia presents a significant challenge for anticoagulation therapy.
Implications:
- Early recognition and management of thrombotic events are crucial in acute leukemia patients.
- Multifaceted prothrombotic factors in leukemia necessitate tailored treatment strategies.
- Balancing anticoagulation with the risk of hemorrhage is critical for patient outcomes.
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