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Clindamycin hydrochloride monohydrate and its ethanol solvate
Krishnan Ravikumar1, Balasubramanian Sridhar
1Laboratory of X-ray Crystallography, Indian Institute of Chemical Technology, Hyderabad 500 007, India. sshiya@yahoo.com
Acta Crystallographica. Section C, Crystal Structure Communications
|February 4, 2010
Summary
This study details the crystal structures of clindamycin hydrochloride monohydrate and its ethanol solvate. The findings reveal consistent molecular conformation and highlight hydrogen bonding networks crucial for understanding this antibiotic's behavior.
Area of Science:
- Crystallography
- Medicinal Chemistry
- Structural Biology
Background:
- Clindamycin hydrochloride is a lincomycin family antibiotic.
- Understanding its crystalline forms is vital for pharmaceutical development.
Purpose of the Study:
- To characterize the crystal structures of clindamycin hydrochloride monohydrate and its ethanol solvate.
- To investigate the hydrogen bonding networks and molecular conformations in these crystalline forms.
Main Methods:
- X-ray crystallography was employed to determine the structures.
- Analysis of intermolecular interactions, including hydrogen bonds, was performed.
Main Results:
- Clindamycin hydrochloride was crystallized as a monohydrate and a monohydrate ethanol solvate.
- The molecular conformation of clindamycin remained consistent across both crystal structures and resembled enzyme-bound forms.
- Both structures exhibited extensive hydrogen bonding networks involving chloride ions, water, and ethanol molecules.
Conclusions:
- The study provides detailed insights into the solid-state structures of clindamycin hydrochloride.
- Hydrogen bonding plays a significant role in the aggregation and stability of its hydrated and solvated crystalline forms.
- These findings contribute to a deeper understanding of clindamycin's physical chemistry and potential interactions.
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