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Related Concept Videos

Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Mandibular periosteal (juxtacortical) chondrosarcoma.

Elisângela Maria Cunha Costa1, Bárbara Lima Lucas, Mariana Reis Silva

  • 1Laboratory of Oral Pathology, Dental School, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Brazilian Dental Journal
|February 4, 2010
PubMed
Summary

Periosteal chondrosarcoma (PC), a rare malignant bone tumor, can occur in the jaw. This case highlights the diagnostic and treatment considerations for this unusual mandibular tumor.

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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle
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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

Area of Science:

  • Oncology
  • Oral and Maxillofacial Surgery
  • Pathology

Background:

  • Periosteal chondrosarcoma (PC) is a well-differentiated malignant cartilage tumor originating from the bone's external surface, typically affecting long bones.
  • While generally having a good prognosis with en-bloc resection, PC is rare in the mandible.
  • This report details an unusual case of PC in the mandibular bone.

Observation:

  • A rare case of PC occurred in the mandible of a 41-year-old male.
  • The lesion presented as a slow-growing, painless swelling with popcorn-like calcifications on CT scan.
  • Biopsy confirmed PC, grade II.

Findings:

  • The patient underwent hemimandibulectomy and complementary radiotherapy (70 Gy).
  • No recurrence or metastasis was observed during an 18-month follow-up period.

Implications:

  • This case underscores the possibility of PC in the mandible, a rare location.
  • Early diagnosis and multimodal treatment are crucial for managing periosteal chondrosarcoma.
  • Further research into the specific characteristics and treatment outcomes of mandibular PC is warranted.