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Updated: Jun 16, 2026
Murine Heterotopic Heart Transplant Technique
Published on: July 8, 2014
IL-17 contributes to the development of chronic rejection in a murine heart transplant model
Satoshi Itoh1, Susumu Nakae, Robert C Axtell
1Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Background:
Although interleukin-17 (IL-17) has been reported to participate in the pathogenesis of infectious, autoimmune and allergic disorders, the precise role in allograft rejection remains uncertain. This study illustrates that IL-17 contributes to the pathogenesis of chronic allograft rejection.
Result:
Utilizing a murine heterotopic heart transplant model system, IL-17-deficient recipient mice had decreased allograft inflammatory cell recruitment, decreased IL-6, MCP-1, and KC production, and reduced graft coronary artery disease (GCAD). Intragraft gamma delta (gammadelta) T cells appear to be the predominant source of IL-17 production.
Conclusion:
Therefore, IL-17 neutralization may provide a potential target for novel therapeutic treatment for cardiac allograft rejection.
