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First report on HLA-DPB1 gene allelic distribution in the general Lebanese population
Dina Shammaa1, Sara Khansa, Ghazi Zaatari
1Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Aims:
Interest in the importance of the HLA-DPB1 gene has increased lately, especially in transplantation outcomes in addition to other HLA CII molecules. This is the first study that assesses HLA-DPB1 typing among healthy Lebanese individuals.
Methods:
The HLA-DPB1 alleles were detected using the polymerase chain reaction/sequence-specific priming method and our study included 130 individuals. HLA-DPB1 was determined in different ethnic groups and in relation to various clinical entities.
Results:
We compared our data with the existing literature and found an interesting similarity between the Lebanese and Greek populations with highly specific alleles not reported in other communities.
Conclusion:
Our study will form the basis for further research to study the correlation between HLA-DPB1 and various clinical entities as well as a primer study for other transplantation centers.
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