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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications.
Bhupinder Singh1, Shantanu Bandopadhyay, Rishi Kapil
1University Institute of Pharmaceutical Sciences (UGC Centre of Advanced Studies), Panjab University, Chandigarh 160 014, India.
Critical Reviews in Therapeutic Drug Carrier Systems
|February 9, 2010
Summary
Self-emulsifying drug delivery systems (SEDDS) enhance oral drug bioavailability by forming nanoemulsions that bypass liver metabolism. This review details SEDDS formulation, characterization, and optimization for improved drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Poorly water-soluble drugs often exhibit low oral bioavailability due to limited absorption.
- Self-emulsifying drug delivery systems (SEDDS) offer a promising strategy to overcome these limitations.
Purpose of the Study:
- To provide a comprehensive review of self-emulsifying drug delivery systems (SEDDS).
- To discuss formulation, characterization, optimization, and applications of SEDDS for enhancing drug bioavailability.
Main Methods:
- Literature and patent review on diverse SEDDS formulations.
- Discussion of characterization techniques for globule size, drug encapsulation, stability, and rheology.
- Overview of in vitro, in situ, and ex vivo methods for assessing drug absorption and permeation.
Main Results:
- SEDDS rapidly form micro/nanoemulsions in gastrointestinal fluids, improving drug solubilization.
- The small globule size facilitates lymphatic absorption, bypassing hepatic first-pass metabolism.
- Various characterization methods are crucial for developing robust and effective SEDDS formulations.
Conclusions:
- SEDDS significantly enhance oral bioavailability of poorly soluble drugs.
- This review provides a guide for researchers and formulators in developing and applying SEDDS.
- Further research into SEDDS applications promises accelerated progress in pharmaceutical development.
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