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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

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Published on: November 16, 2011

Glucose clamp algorithms and insulin time-action profiles.

B Wayne Bequette1

  • 1Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180-3590, USA. bequette@rpi.edu

Journal of Diabetes Science and Technology
|February 11, 2010
PubMed
Summary
This summary is machine-generated.

Insulin on board (IOB) curves are crucial for artificial pancreas systems. Simulation shows glucose meter bias and noise have minimal impact on IOB profiles, suggesting handheld meters are viable for clamp studies with data filtering.

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Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Control Systems

Background:

  • Insulin on board (IOB) is a key feature in insulin pumps and artificial pancreas systems to prevent hypoglycemia.
  • IOB curves are derived from insulin pharmacodynamics, typically determined through glycemic clamp studies.

Purpose of the Study:

  • To analyze the impact of glucose meter bias and noise on glycemic control and insulin time-activity profiles.
  • To evaluate the robustness of IOB curve generation in the presence of measurement inaccuracies.

Main Methods:

  • Review of glycemic clamp algorithms.
  • In silico studies simulating glucose meter bias and noise.
  • Generation of IOB curves from simulated insulin time-activity profiles.

Main Results:

  • A systematic glucose meter bias of +6 mg/dl minimally affected IOB profiles.
  • Glucose meter noise and bias showed a 3% decrease in glucose area under the curve but no significant change in IOB.
  • Model-based controllers demonstrated equivalence to PI control with time-delay compensation.

Conclusions:

  • Significant glucose meter bias and noise can be tolerated in clamp studies without substantially altering IOB curves.
  • Handheld glucose meters may be suitable for clamp studies if measurements are filtered.
  • Further clinical studies are required to validate these simulation findings.