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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test

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Published on: March 23, 2013

Cheese is a reliable alternative meal for solid-phase gastric emptying study.

Laura A Drubach¹, Vasiliki Kourmouzi, Frederic H Fahey

¹Department of Radiology, Division of Nuclear Medicine/PET, Children's Hospital Boston, MA, USA. laura.drubach@childrens.harvard.edu

Nuclear Medicine Communications

|February 11, 2010

Summary

Cheddar cheese demonstrates stable labeling for gastric emptying studies, offering a viable alternative to egg whites for pediatric patients. Oatmeal and mashed potatoes showed poor stability and are not recommended for this procedure.

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Area of Science:

Nuclear medicine
Gastroenterology
Pediatric studies

Background:

Solid-phase gastric emptying studies are crucial for diagnosing gastrointestinal motility disorders.
Cooked egg whites labeled with technetium-99m sulfur colloid are a standard but not universally accepted meal choice.
Alternative meal options are needed, especially for pediatric populations with dietary restrictions or aversions.

Purpose of the Study:

To evaluate the labeling stability of alternative meals for solid-phase gastric emptying studies.
To identify suitable alternatives to egg whites for pediatric patients.

Main Methods:

Several meals (egg whites, cheese, oatmeal, mashed potatoes, peanut butter) were labeled with technetium-99m sulfur colloid.
Labeled meals were incubated with gastric juice and agitated for 1 and 4 hours.
Radioactivity remaining with the solid phase was measured after filtration to assess labeling stability.

Main Results:

Egg whites and cheddar cheese exhibited high and stable labeling percentages at both 1 and 4 hours (98.2% and 95.6% at 1h; 98.5% and 95.8% at 4h, respectively).
Oatmeal, mashed potatoes, and peanut butter showed significantly lower and more variable labeling stability.
Cheddar cheese labeling stability was comparable to egg whites, with no significant difference between 1 and 4 hours.

Conclusions:

Cheddar cheese is a suitable and stable alternative meal for solid-phase gastric emptying studies in children.
Oatmeal and mashed potatoes are not recommended due to poor and variable labeling stability.
Expanding meal choices, like cheddar cheese, is essential for accommodating pediatric patients' preferences and needs in gastric emptying assessments.