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2024 Update of the North American Consensus Guidelines for Pediatric Administered Radiopharmaceutical Activities
S Ted Treves1, Frederic H Fahey2, Valentina Ferrer Valencia3
1Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Journal of Nuclear Medicine Technology
|July 15, 2025
Summary
The 2024 North American guidelines for pediatric radiopharmaceutical activities were updated by experts. These guidelines now include modified and new protocols for pediatric nuclear medicine, enhancing diagnostic accuracy.
Area of Science:
- Nuclear Medicine
- Pediatric Imaging
- Radiopharmaceutical Therapy
Background:
- The previous North American consensus guidelines for pediatric administered radiopharmaceutical activities (NAGL) were last updated in 2016.
- Advances in imaging technology and radiopharmaceuticals necessitate guideline revisions.
Purpose of the Study:
- To systematically review and update the 2016 NAGL for pediatric diagnostic nuclear medicine.
- To incorporate recent advancements in equipment, processing, and radiopharmaceutical agents.
Main Methods:
- A working group of 19 pediatric nuclear medicine experts convened for 2 years.
- Systematic review of existing protocols for pertinence, modification needs, and potential additions.
- Inclusion of new protocols based on current clinical practice and technological advancements.
Main Results:
- The 2024 NAGL update was approved by the Image Gently Alliance.
- No existing protocols were removed; 9 were modified, and 6 new protocols were added.
- Six new protocols include cardiac imaging agents (13N-NH3, 83Rb) and thyroid cancer imaging agents (18F-DOPA, 68Ga-DOTATATE, 68Ga-DOTATOC, Na123I).
Conclusions:
- The updated 2024 NAGL reflect the increasing use of PET imaging in pediatric nuclear medicine.
- These revised guidelines address technological progress and new radiopharmaceuticals for improved pediatric patient care.
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