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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Updated: Jun 16, 2026

Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System
09:16

Efficient Generation and Editing of Feeder-free IPSCs from Human Pancreatic Cells Using the CRISPR-Cas9 System

Published on: November 8, 2017

Is iPS cell the panacea?

Li Ou1, Xiaochen Wang, Fangdong Zou

  • 1Sichuan University, Chengdu, People's Republic of China.

IUBMB Life
|February 11, 2010
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem (iPS) cells, generated from four transcription factors, offer great potential but face challenges. This review highlights critical issues like origin, tumor risk, and natural selection links for iPS cell research.

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Area of Science:

  • Stem cell biology
  • Epigenetics
  • Developmental biology

Background:

  • Reprogramming somatic cells into induced pluripotent stem (iPS) cells is achievable using four transcription factors (c-Myc, Klf4, Oct4, and Sox2).
  • iPS cells hold significant promise for regenerative medicine, drug discovery, and fundamental biological research.
  • Despite their potential, critical challenges and limitations associated with iPS cells remain underexplored.

Purpose of the Study:

  • To critically review the significant problems and challenges associated with induced pluripotent stem (iPS) cells.
  • To investigate the elusive origin and potential tumorigenic risks inherent in iPS cell technology.
  • To explore the relationship between iPS cells and natural selection mechanisms.

Main Methods:

  • Literature review and critical analysis of existing research on iPS cells.
  • Examination of studies focusing on the reprogramming process and pluripotency.
  • Synthesis of information regarding the safety and biological implications of iPS cells.

Main Results:

  • The origin of iPS cells is not fully understood, posing fundamental questions.
  • A significant risk of tumorigenesis is associated with the use of iPS cells.
  • The interplay between iPS cell generation and natural selection requires further investigation.

Conclusions:

  • Addressing the inherent problems of iPS cells is crucial for their safe and effective application.
  • Further research is needed to elucidate the origin, mitigate tumorigenesis risks, and understand the evolutionary context of iPS cells.
  • Overcoming these challenges will unlock the full therapeutic and research potential of iPS cell technology.