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Methodology of systematic reviews and recommendations
Julio C Furlan1, Jeffrey Singh, Jane Hsieh
1Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Ontario, Canada.
Journal of Neurotrauma
|February 12, 2010
Summary
This study synthesizes research on acute traumatic spinal cord injury (SCI) to create evidence-based recommendations. Experts developed guidelines to improve clinical practice and guide future SCI research directions.
Area of Science:
- Neuroscience
- Traumatology
- Evidence-Based Medicine
Background:
- Spinal cord injury (SCI) research has rapidly expanded over the past two decades.
- A wide range of journals publish studies on this complex subspecialty.
- Existing literature on acute traumatic SCI requires synthesis to inform current practice.
Purpose of the Study:
- To summarize existing literature on 12 key topics in acute traumatic SCI.
- To develop evidence-based recommendations for clinical practice.
- To identify future research priorities in SCI.
Main Methods:
- A multidisciplinary expert panel formulated consensus-based questions.
- Systematic literature reviews were conducted using multiple databases (MEDLINE, CINAHL, EMBASE, Cochrane).
- Delphi methodology and anonymized voting were used to generate recommendations with 80% consensus.
Main Results:
- Evidence-based answers to targeted questions were formulated.
- Recommendations were generated to bridge the gap between SCI science and clinical application.
- Key areas for future SCI research were identified.
Conclusions:
- The study provides a consensus-driven summary of current SCI knowledge.
- Recommendations aim to enhance the translation of SCI research into clinical practice.
- This work establishes a foundation for advancing SCI treatment and management.
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