Related Experiment Video
Updated: Jun 16, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
Published on: May 2, 2025
Advances in the treatment of neurodegenerative disorders employing nanotechnology
Girish Modi1, Viness Pillay, Yahya E Choonara
1Department of Neurology, Division of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa. gmodicns@mweb.co.za
Abstract:
Due to limitations posed by the restrictive blood-brain barrier, conventional drug delivery systems do not provide adequate cyto-architecture restoration and connection patterns that are essential for functional recovery in neurodegenerative disorders (NDs). Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of NDs by stimulating, responding to, and interacting with target sites to induce physiological responses while minimizing side effects. This review provides a concise discussion of the current applications of nano-enabled drug-delivery systems for the treatment of NDs, in particular Alzheimer's and Parkinson's diseases, and explores the future applications of nanotechnology in clinical neuroscience to develop innovative therapeutic modalities for the treatment of NDs.
More Related Videos
08:37Focused Ultrasound Induced Blood-Brain Barrier Opening for Targeting Brain Structures and Evaluating Chemogenetic Neuromodulation
Published on: December 22, 2020
04:41Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice
Published on: February 24, 2026
Related Concept Videos
Alzheimer's Disease: Treatment
Parkinson's Disease: Overview
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Microorganisms in Medicine and Therapeutics
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists