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A concise enantioselective synthesis of (-)-ranirestat

Barry M Trost1, Maksim Osipov, Guangbin Dong

  • 1Department of Chemistry, Stanford University, Stanford, California 94305, USA. bmtrost@stanford.edu

Organic Letters
|February 13, 2010
PubMed
Summary

Researchers developed an efficient, enantioselective synthesis for ranirestat, a potent aldose reductase inhibitor. This method uses affordable starting materials and a key palladium-catalyzed asymmetric allylic alkylation to create the drug

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