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Pharmacogenomics: Identification of New Drug Targets

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Updated: Jun 16, 2026

Using Microtiter Dish Radiolabeling for Multiple In Vivo Measurements Of Escherichia coli (p)ppGpp Followed by Thin Layer Chromatography
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[Recent advances in PPARgamma research].

Hironori Waki1, Toshimasa Yamauchi, Takashi Kadowaki

  • 1Department of Metabolic Diseases, Graduate School of Medicine, the University of Tokyo.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 18, 2010
PubMed
Summary
This summary is machine-generated.

Peroxisome proliferator-activated receptor gamma (PPARgamma) regulates fat cell differentiation and influences inflammation, atherosclerosis, and bone development. Recent research reveals its diverse pathophysiological roles beyond diabetes treatment.

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Last Updated: Jun 16, 2026

Using Microtiter Dish Radiolabeling for Multiple In Vivo Measurements Of Escherichia coli (p)ppGpp Followed by Thin Layer Chromatography
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Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay (DRaCALA)
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Identifying the Binding Proteins of Small Ligands with the Differential Radial Capillary Action of Ligand Assay (DRaCALA)

Published on: March 19, 2021

Area of Science:

  • Endocrinology and Metabolism
  • Molecular Biology
  • Cell Biology

Context:

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor protein.
  • It is a key target for thiazolidinedione antidiabetic medications.
  • Initially recognized for its role in adipocyte differentiation.

Purpose:

  • To summarize recent advancements in understanding PPARgamma's biological functions.
  • To highlight the diverse pathophysiological roles of PPARgamma.

Summary:

  • PPARgamma regulates adipokine expression and inflammatory mediators.
  • It influences adipose tissue macrophage polarization.
  • Emerging roles in atherosclerosis and bone development are discussed.

Impact:

  • Provides updated insights into PPARgamma's multifaceted biological actions.
  • Highlights potential therapeutic targets beyond diabetes.
  • Contributes to the understanding of metabolic and inflammatory diseases.