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Updated: Jun 16, 2026

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
06:29

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells

Published on: July 30, 2020

TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression.

Tomokazu Ohishi1, Toru Hirota, Takashi Tsuruo

  • 1Division of Molecular Biotherapy, Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan.

Cancer Research
|February 18, 2010
PubMed
Summary

Overexpressed Aurora-A kinase causes mitotic defects by phosphorylating the telomeric protein TRF1. Inhibiting TRF1 phosphorylation prevents these abnormalities, suggesting a new therapeutic target for cancer.

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