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Salt bridge integrates GPCR activation with protein trafficking.

Jo Ann Janovick1, P Michael Conn

  • 1Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA.

Proceedings of the National Academy of Sciences of the United States of America
|February 18, 2010
PubMed
Summary

A specific salt bridge in G protein-coupled receptors (GPCRs) is crucial for correct protein trafficking. Disrupting this bridge leads to constitutive activity, revealing its role in receptor activation and cell protection.

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