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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Updated: Jun 16, 2026

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
04:59

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Published on: July 7, 2023

Interventions for preventing posterior capsule opacification.

Oliver Findl1, Wolf Buehl, Peter Bauer

  • 1Department of Ophthalmology, Hanusch Hospital, Heinrich-Collin-Strasse 30, Vienna, Austria, A-1140.

The Cochrane Database of Systematic Reviews
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

Sharp-edged intraocular lenses (IOLs) significantly reduce posterior capsule opacification (PCO) after cataract surgery. IOL material and anti-inflammatory treatments showed no significant impact on PCO development.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science

Background:

  • Posterior capsule opacification (PCO) is the most frequent long-term complication following cataract surgery.
  • Nd:YAG laser capsulotomy is a treatment option but carries risks and is inaccessible in many regions.
  • Research is ongoing to identify factors influencing PCO development.

Purpose of the Study:

  • To systematically review interventions aimed at inhibiting PCO.
  • Interventions include surgical techniques, intraocular lens (IOL) design modifications, additional devices, and pharmacological treatments.

Main Methods:

  • A comprehensive search of CENTRAL, MEDLINE, EMBASE, and LILACS databases was conducted in March 2009.
  • Inclusion criteria were prospective, randomized, controlled trials with a minimum 12-month follow-up.
  • Data on visual acuity, PCO scores, and YAG capsulotomy rates were extracted and meta-analyzed.

Main Results:

  • No significant difference in PCO development was observed between different IOL materials (PMMA, hydrogel, acrylic, silicone).
  • Sharp-edged IOLs demonstrated significantly lower PCO scores and YAG rates compared to round-edged IOLs.
  • No significant differences in PCO rates were found for various anti-inflammatory treatments, except for immunotoxin (MDX-A).

Conclusions:

  • Intraocular lenses with sharp posterior optic edges are recommended to minimize PCO.
  • There is no clear advantage of specific IOL optic materials in preventing PCO.
  • Postoperative anti-inflammatory treatment choice does not appear to significantly influence PCO development.