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Focusing of Light in the Eye01:16

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Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
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Intraindividual Comparison of Two Refractive Extended-Depth-of-Focus Intraocular Lens Designs.

Johannes Zeilinger1, Stefan Palkovits1, Manuel Ruiss1

  • 1From the Vienna Institute for Research in Ocular Surgery (VIROS), Department of Ophthalmology, Hanusch Hospital, Vienna, Austria.

American Journal of Ophthalmology
|April 27, 2026
PubMed
Summary
This summary is machine-generated.

This study compared two extended-depth-of-focus intraocular lenses (IOLs) for cataract surgery. The AN6V IOL showed better intermediate vision (UIVA) than the DEN00V IOL, though both provided good overall visual performance.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Vision Science

Background:

  • Cataract surgery often involves intraocular lens (IOL) implantation to restore vision.
  • Extended-depth-of-focus (EDF) IOLs aim to provide a continuous range of vision, reducing spectacle dependence.
  • Non-diffractive refractive EDF IOLs offer an alternative approach to achieving extended depth of focus.

Purpose of the Study:

  • To compare the visual performance of two distinct non-diffractive refractive extended-depth-of-focus (EDF) intraocular lenses (IOLs).
  • To evaluate intra-individual differences in visual outcomes between a wavefront-shaped EDF IOL (DEN00V) and a sector-segmented EDF IOL (AN6V).

Main Methods:

  • A prospective, randomized, patient- and examiner-masked, intra-individual comparative study was conducted.
  • Forty patients with bilateral age-related cataracts received either the DEN00V or AN6V EDF IOL in fellow eyes.
  • Visual acuity (UDVA, UIVA, UNVA), refractive outcomes, defocus curves, contrast sensitivity, halometry, and subjective visual quality were assessed after 3 months.

Main Results:

  • Both IOLs provided comparable uncorrected distance visual acuity (UDVA) and uncorrected near visual acuity (UNVA).
  • The primary endpoint, uncorrected intermediate visual acuity (UIVA), was significantly better with the AN6V IOL (0.12±0.09 logMAR) compared to the DEN00V IOL (0.18±0.13 logMAR).
  • Nominal differences favoring the AN6V IOL were observed for corrected distance visual acuity (CDVA) and UNVA, but these did not remain statistically significant after multiple comparisons.

Conclusions:

  • Both non-diffractive refractive EDF IOLs provide an extended range of functional vision and preserve contrast sensitivity.
  • The AN6V IOL demonstrated a statistically significant advantage in uncorrected intermediate visual acuity (UIVA) compared to the DEN00V IOL.
  • Both IOLs exhibited minimal photopic phenomena, contributing to good subjective visual quality.