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Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...

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Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels
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Self-assemblies on chitosan nanohydrogels.

Fabrice Brunel1, Laurent Véron, Laurent David

  • 1Université de Lyon, Université Lyon 1, Laboratoire des Matériaux Polymères et des Biomatériaux, UMR CNRS 5223 Ingénierie des Matériaux Polymères, Bât. ISTIL, 15 bd A. Latarjet, 69622 - Villeurbanne, France.

Macromolecular Bioscience
|February 19, 2010
PubMed
Summary
This summary is machine-generated.

Researchers created eco-friendly chitosan nanohydrogels using physical gelation. These versatile nanocarriers effectively load biomolecules like immunoglobulins, showing promise for drug delivery applications in life sciences.

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ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
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ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Chitosan, a natural polymer, is biocompatible and biodegradable.
  • Developing safe and effective nanocarriers for bioactive molecules is crucial for drug delivery.
  • Physical gelation offers an alternative to chemical cross-linking, avoiding toxic solvents.

Purpose of the Study:

  • To synthesize pure chitosan nanohydrogels via ammonia-induced physical gelation.
  • To investigate the assembly of macromolecules, including proteins and polysaccharides, with these nanohydrogels.
  • To evaluate the potential of these nanohydrogels as versatile carriers for biomolecules.

Main Methods:

  • Reverse emulsion of chitosan in a triglyceride mixture.
  • Ammonia-induced physical gelation for nanohydrogel formation.
  • Characterization of nanohydrogel size, surface charge, and macromolecule loading capacity.

Main Results:

  • Chitosan nanohydrogels were successfully synthesized with controlled size and positive surface charge.
  • Chondroitin sulfate formed polyelectrolyte complexes, resulting in negatively charged hydrogels.
  • Immunoglobulin loading capacity was significantly higher with negatively charged nanohydrogels compared to positively charged ones.

Conclusions:

  • Fully biodegradable, submicrometric physical hydrogels can be produced from natural polymers.
  • Chitosan nanohydrogels demonstrate tunable surface properties and versatile biomolecule loading capabilities.
  • These nanohydrogels hold significant potential as carriers in various life science applications.