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Related Experiment Video

Updated: Jun 16, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans

Prostaglandin Extraction and Analysis in Caenorhabditis elegans

Published on: June 25, 2013

Eicosanoids and cancer.

Dingzhi Wang¹, Raymond N Dubois

¹Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA.

Nature Reviews. Cancer

|February 20, 2010

Summary

Eicosanoids, like prostaglandins, are lipids involved in cancer. Understanding their role in tumor microenvironments is key to developing new cancer treatments.

Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Eicosanoids are biologically active lipids, including prostaglandins and leukotrientes.
These lipids play significant roles in pathological processes such as inflammation and cancer.

Purpose of the Study:

To review the complex roles of eicosanoids in epithelial-derived tumors.
To highlight the importance of eicosanoids in the tumor microenvironment.
To understand lipid orchestration of interactions between cancer cells and stromal cells.

Main Methods:

Literature review of eicosanoid involvement in cancer.
Analysis of molecular mechanisms in cancer progression.
Synthesis of knowledge on eicosanoids and tumor evolution.

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Published on: April 24, 2015

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Last Updated: Jun 16, 2026

Prostaglandin Extraction and Analysis in Caenorhabditis elegans

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A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

Published on: April 24, 2015

Main Results:

Eicosanoids significantly influence epithelial-derived tumors and their microenvironments.
These lipids mediate complex interactions between transformed epithelial cells and stromal cells.
Understanding these interactions is vital for tumor evolution, progression, and metastasis.

Conclusions:

Eicosanoids are critical players in cancer development and progression.
Further understanding of eicosanoid molecular mechanisms can lead to novel chemopreventive and therapeutic strategies.
Targeting eicosanoid pathways may offer new avenues for cancer treatment.