Related Experiment Video
Updated: Jun 16, 2026
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
[Infectious endophthalmitis after cataract extraction, a serious complication]
Christiaan Wesselink1, Steven A Koopmans, Leonoor I Los
1Universitair Medisch Centrum Groningen, Rijksuniversiteit Groningen, afd. Oogheelkunde, Groningen, The Netherlands. c.wesselink@ohk.umcg.nl
Nederlands Tijdschrift Voor Geneeskunde
|February 23, 2010
Summary
Cataract surgery, a common procedure, can lead to endophthalmitis, an eye infection. Early recognition and treatment are crucial for acute cases, while chronic infections require careful management.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Cataract extraction with lens implantation is a globally prevalent and generally safe surgical procedure.
- The implantation of an intraocular lens introduces a risk of infectious complications, specifically endophthalmitis, due to bacterial adherence.
Observation:
- Presents two cases illustrating acute and chronic postoperative endophthalmitis.
- Acute endophthalmitis is a severe condition requiring immediate diagnosis and treatment.
- Chronic endophthalmitis is a persistent, low-virulence infection that poses diagnostic challenges and necessitates careful treatment considerations.
Findings:
- Bacterial adherence to the implanted foreign body (intraocular lens) is the primary mechanism for endophthalmitis development.
- The clinical presentation and management strategies differ significantly between acute and chronic forms of postoperative endophthalmitis.
Implications:
- Risk assessment for infectious complications should precede cataract surgery, balancing potential benefits against infection risks.
- Understanding the nuances of acute versus chronic endophthalmitis is vital for effective patient management and visual outcome preservation.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:22Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:25Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...