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Updated: Jun 16, 2026
Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
Published on: November 20, 2018
Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation
Vincent Rerat1, Sophie Laurent, Carmen Burtéa
1Unité de Chimie Organique et Médicinale, Université Catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.
Abstract:
Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).
