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An Intra-Tissue Radiometry Microprobe for Measuring Radiance In Situ in Living Tissue
Published on: June 2, 2023
Reflectometry, ablation and fluid retrieval with an optical fiber.
A Sudirman1, G Björk, W Margulis
1Department of Fiber Photonics, Acreo AB, Electrum 236, 16440 Stockholm, Sweden. Aziza.Sudirman@acreo.se
Optics Express
|February 23, 2010
Summary
A novel technique integrates laser ablation, microfluidics, and low-coherence reflectometry within a microstructured fiber. This method enables precise material ablation and simultaneous fluid collection, minimizing contamination risk for sample retrieval.
Area of Science:
- Optoelectronics
- Biomedical Engineering
- Materials Science
Background:
- Microfluidic systems are crucial for sample manipulation.
- Laser ablation offers precise material processing.
- Low-coherence reflectometry is a non-invasive metrology technique.
Purpose of the Study:
- To develop an integrated microstructured fiber system.
- To combine laser ablation, microfluidics, and low-coherence reflectometry.
- To demonstrate simultaneous sample ablation and fluid collection with real-time monitoring.
Main Methods:
- A microstructured fiber was engineered to house microfluidic channels.
- Nd:YAG laser light was guided through the fiber for ablation.
- Low-coherence reflectometry was employed for precise fiber positioning and fluid collection monitoring.
Main Results:
- Successful ablation of thin aluminum foil samples was achieved.
- Liquid sample collection within the fiber's microfluidic channels was demonstrated.
- Simultaneous monitoring of ablation positioning and fluid collection was confirmed.
Conclusions:
- The integrated fiber system offers a versatile platform for minimally invasive procedures.
- The technique shows potential for low-contamination liquid sample retrieval.
- This approach advances in situ material processing and sample handling.

