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MicroRNA analysis for outcome prediction in hepatitis B virus-related liver cancer

Loreto Boix1, Jordi Bruix

  • 1BCLC Group, Liver Unit, Hospital Clínic, Centro de Investigación Biomédica en Red, de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain.

Gastroenterology
|February 24, 2010
PubMed
Abstract

No abstract available in PubMed .

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MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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