Related Experiment Video
Updated: May 11, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
Drug allergy
David A Khan1, Roland Solensky
1University of Texas Southwestern Medical Center, Dallas, TX 75390-8859, USA. dave.khan@utsouthwestern.edu
Abstract:
Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. A thorough history is essential to the management of drug allergy. Laboratory testing has a very limited role in the management of drug allergy. Graded dose challenges and procedures to induce drug tolerance might be required in patients with drug allergy when there is a definite need for a particular agent. Management of reactions to specific agents, including beta-lactam antibiotics, sulfonamides, local anesthetics, radiocontrast media, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, and biologic modifiers, will be discussed in further detail.
Related Concept Videos
Cross-reactivity
Allergic Reactions
Allergic Drug Reactions
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions
Allergic Reactions: Anaphylaxis

