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![Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F55537.jpg&w=3840&q=50)
Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases
Published on: May 29, 2017
Point-like radioactive source with multiple absorber capsules for evaluating PET scanners
Tomoyuki Hasegawa1, Eiji Yoshida, Yasushi Sato
1School of Allied Health Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa, 228-8555, Japan. hasegawa@kitasato-u.ac.jp
Objective:
Radioactive sources for evaluating sensitivity and uncertainty in the radioactivity measurements performed using PET scanners must be equipped with absorber materials that ensure the annihilation of positrons. Attenuation and scattering owing to the absorber materials produce uncertainty in the performance evaluation. The aim of this study is to propose a point-like radioactive source with multiple absorber capsules, for which evaluation can be independent of scatter and attenuation owing to the source absorbers.
Methods:
The point-like source consists of a small spherical radioactive part and a set of successively sized cylindrical aluminum absorber capsules. Data were collected for different total absorber thicknesses. By an extrapolation technique, the effects of the source absorbers were eliminated. Sensitivity and uncertainty in the radioactivity measurements of PET scanners were evaluated with this technique.
Results:
Sensitivity and uncertainty of radioactivity measurement to the point-like radioactive source were evaluated successfully with this method.
Conclusion:
The proposed point-like radioactive source is useful for evaluating performance characteristics of PET scanners in a way that is independent of the effects of the source absorbers.
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