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Tumor necrosis factor alpha, interleukin-6 and interleukin-10 polymorphisms in preeclampsia
Pervin Vural1, Sevgin Degirmencioglu, Neslihan Y Saral
1Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. pervinvural@yahoo.com
Insights
The interleukin-10 (IL-10) gene variant (-1082 A allele) is linked to a higher risk of preeclampsia (PE). This genetic factor may influence PE development, independent of metabolic changes.
Area of Science:
- Obstetrics and Gynecology
- Immunogenetics
- Reproductive Medicine
Background:
- Preeclampsia (PE) is a severe pregnancy complication.
- Cytokine imbalances may contribute to PE etiology.
- Investigating genetic predispositions is crucial for understanding PE.
Purpose of the Study:
- To determine if cytokine gene polymorphisms are associated with PE.
- To explore the relationship between specific genotypes and PE clinical/laboratory features.
Main Methods:
- Analyzed single nucleotide polymorphisms (SNPs) in TNFalpha(-308), IL-6(-174), and IL-10(-1082) genes.
- Utilized DNA from 101 PE patients and 95 healthy controls.
- Compared allele and genotype frequencies between groups.
Main Results:
- Increased IL-10 (-1082) A allele frequency observed in PE patients (P=0.04).
- No significant differences in TNFalpha(-308) or IL-6(-174) gene variants between PE and control groups.
- IL-10 (-1082) A allele carriers showed higher glucose and lower HDL-cholesterol levels.
Conclusions:
- The IL-10 (-1082) A allele is associated with an increased risk of preeclampsia.
- Women with the IL-10 (-1082) AA genotype have a 3.38-fold increased risk of PE.
- This genetic association appears independent of metabolic effects.
Aim:
Preeclampsia (PE) is one of the most serious disorders of pregnancy. The imbalance between pro- and anti-inflammatory cytokines may play a role in its etiology. The aim of the present study was to investigate whether cytokine gene polymorphism is associated with PE, and to evaluate the relationship between genotypes and clinical/laboratory manifestation of PE.
Methods:
We investigated single nucleotide polymorphisms of tumor necrosis factor (TNF)alpha(-308 G/A), interleukin (IL)-6 (-174 G/C), IL-10 (-1082 G/A) genes in DNA from peripheral blood leukocytes of 101 PE patients and 95 healthy control women.
Results:
In PE, there was a significant increase of the IL-10 (-1082) A allele frequency (P = 0.04). No significant differences were found in genotypes or allele frequencies of TNFalpha(-308) and IL-6 (-174) genes between PE women and controls. While TNFalpha(-308) and IL-6 (-174) genotypes did not influence clinical/laboratory parameters in PE, IL-10 (-1082) A allele carrying genotypes (AG + AA) were associated with higher glucose and lower HDL-cholesterol levels.
Conclusion:
Because women with IL-10 (-1082) AA genotype have 3.38-fold increased risk of developing PE according to GG genotype (95% CI 1.21-9.4, P = 0.01), we suggest that IL-10 (-1082) variant A allele is associated with an increased risk of preeclampsia, which is independent from its metabolic effects.
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