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Related Experiment Video

Updated: Jun 15, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

White matter structural decline in normal ageing: a prospective longitudinal study using tract-based spatial

Thomas R Barrick¹, Rebecca A Charlton, Chris A Clark

¹Centre for Clinical Neuroscience, St. George's, University of London, Cranmer Terrace, London, SW17 0RE, UK. tbarrick@sgul.ac.uk

|February 25, 2010

Summary

This summary is machine-generated.

Diffusion tensor imaging (DTI) can detect age-related white matter changes over two years. Longitudinal analysis revealed widespread brain changes, not accelerated decline in the frontal lobe.

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Area of Science:

Neuroimaging
Gerontology
Biomedical Engineering

Background:

Normal aging involves cognitive decline, with white matter degeneration implicated but not fully understood.
Diffusion tensor imaging (DTI) studies support white matter degeneration's role, yet patterns and rates of age-related changes require clarification.
Key questions include the rate of DTI parameter changes over time and regional variations in degeneration.

Purpose of the Study:

To quantify white matter structural integrity changes using DTI in healthy adults aged 50-90.
To determine if regional differences in the rate of white matter degeneration are apparent during longitudinal follow-up.
To investigate age-related structural changes on a voxel-by-voxel basis over a two-year period.

Main Methods:

Utilized diffusion tensor imaging (DTI) techniques to assess white matter integrity.
Employed longitudinal analysis over a two-year follow-up period in healthy adults (50-90 years).
Investigated changes in fractional anisotropy, axial diffusivity, and radial diffusivity using 1D, 2D, and 3D (TBSS) methods.

Main Results:

DTI successfully detected age-related white matter structure changes within a relatively short follow-up duration.
Longitudinal analyses demonstrated significant white matter integrity changes across the entire brain.
No evidence of accelerated white matter degeneration was found specifically in the frontal lobe regions over the two-year period.

Conclusions:

DTI is a viable method for detecting longitudinal, age-related white matter changes.
White matter integrity declines throughout the brain with age, not disproportionately in the frontal lobes.
Findings contribute to understanding the mechanisms of cognitive decline during normal aging.