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Updated: Jun 15, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Nanofluidics in chemical analysis.

Aigars Piruska1, Maojun Gong, Jonathan V Sweedler

  • 1Department of Chemical and Biomolecular Engineering and Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.

Chemical Society Reviews
|February 25, 2010
PubMed
Summary
This summary is machine-generated.

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Nanofluidic devices enable advanced chemical analysis of limited samples by leveraging unique nanoscale flow physics. This review covers nanopore manipulations and their integration with microfluidics for applications like sensing and molecule analysis.

Area of Science:

  • Chemical Analysis
  • Nanotechnology
  • Fluid Dynamics

Background:

  • Nanofluidic devices offer unique advantages for chemical analysis, particularly with mass-limited samples.
  • Understanding the distinct flow physics at the nanoscale, including concentration polarization at interfaces, is crucial.
  • Existing microscale systems face limitations that nanofluidics can overcome.

Purpose of the Study:

  • To provide a critical review of nanofluidic architectures and devices.
  • To discuss the fundamental flow physics differentiating nanoscale from microscale systems.
  • To highlight chemical manipulations and applications enabled by nanofluidics.

Main Methods:

  • Discussion of fundamental flow physics in nanoscale structures.
  • Analysis of concentration polarization at nanofluidic/microfluidic interfaces.

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Fluorescence detection methods for microfluidic droplet platforms
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Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
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Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

Related Experiment Videos

Last Updated: Jun 15, 2026

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Fluorescence detection methods for microfluidic droplet platforms
14:16

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles
11:13

Creating Sub-50 Nm Nanofluidic Junctions in PDMS Microfluidic Chip via Self-Assembly Process of Colloidal Particles

Published on: March 13, 2016

  • Review of chemical manipulations within nanopores (separations, sensing, single molecule measurements).

    • Main Results:

    • Nanofluidic devices demonstrate significant impact in chemical analysis of limited samples.
    • Concentration polarization is a key phenomenon at nanofluidic/microfluidic interfaces.
    • Nanopore-mediated chemical manipulations and integration with 3D microfluidics offer powerful applications.

    Conclusions:

    • Nanofluidics is revolutionizing chemical analysis, especially for minute sample volumes.
    • The integration of nanofluidic structures with microfluidic networks enhances capabilities for sample handling and analysis.
    • Applications include advanced sensing, molecular analysis, and efficient mixing.