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Neural correlates of emotion processing in typically developing children and children of diabetic mothers

Ingrid M Cordón1, Michael K Georgieff, Charles A Nelson

  • 1Center for Public Policy Research, University of California-Davis, Davis, California, USA.

Developmental Neuropsychology
|February 26, 2010
PubMed

Insights

Children born to diabetic mothers (CDMs) show lasting neurocognitive differences. Event-related potentials (ERPs) reveal subtle attention and memory processing impairments in CDMs, persisting into early childhood.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatric Endocrinology

Background:

  • Maternal diabetes during pregnancy can impact fetal neurodevelopment.
  • Previous research suggests potential cognitive and behavioral effects in children born to diabetic mothers (CDMs).
  • Understanding the long-term neurocognitive sequelae in CDMs is crucial for early intervention.

Purpose of the Study:

  • To investigate the neurocognitive sequelae in children born to diabetic mothers (CDMs).
  • To analyze event-related potentials (ERPs) in response to facial expressions in CDMs and controls.
  • To track neurocognitive development from infancy to early childhood in CDMs.

Main Methods:

  • Collected event-related potentials (ERPs) from 42 children (18 CDMs, 24 controls) at 36 and 48 months of age.
  • Presented participants with visual stimuli of three facial expressions: happy, fear, and anger.
  • Utilized a linear mixed models approach to analyze amplitude and latency variations in ERPs.

Main Results:

  • Infant CDMs exhibited subtle ERP-indicated impairments in attention, memory, and face recognition.
  • At 3-4 years old, CDMs continued to show distinct ERP patterns compared to controls.
  • Differences in amplitude, latency, and hemispheric asymmetry were observed in CDMs' ERPs.

Conclusions:

  • CDMs demonstrate persistent neurocognitive differences detectable via ERPs.
  • These findings highlight the lasting effects of maternal diabetes on child neurodevelopment.
  • Early identification and support for CDMs may be warranted based on these neurocognitive differences.

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