Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

N400 and semantic categorization in schizophrenia.

C Grillon1, R Ameli, W M Glazer

  • 1Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06510-3223.

Biological Psychiatry
|March 1, 1991
PubMed
Summary

Schizophrenic patients showed reduced and delayed N400 brain responses during a word task. These abnormalities in event-related potentials (ERPs) suggest impaired semantic processing and information delays in some individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anxiety makes time pass quicker: neural correlates.

Social cognitive and affective neuroscience·2026
Same author

Early Detection of Underlying Cavernomas in Patients with Spontaneous Acute Intracerebral Hematomas.

AJNR. American journal of neuroradiology·2023
Same author

Comparison of magnetic resonance angiography techniques to brain digital subtraction arteriography in the setting of mechanical thrombectomy: A non-inferiority study.

Revue neurologique·2022
Same author

Methylphenidate modulates interactions of anxiety with cognition.

Translational psychiatry·2021
Same author

Primary intracranial germinoma mimicking meningioma in an elderly patient.

Revue neurologique·2021
Same author

Multifocal arterial wall contrast - enhancement in ischemic stroke: A mirror of systemic inflammatory response in acute stroke.

Revue neurologique·2020

Area of Science:

  • Cognitive Neuroscience
  • Clinical Psychology
  • Psychophysiology

Background:

  • The N400 component of event-related potentials (ERPs) is a well-established electrophysiological marker of semantic processing.
  • Schizophrenia is a complex psychiatric disorder often associated with cognitive deficits, including impairments in language and semantic memory.

Purpose of the Study:

  • To investigate the N400 component in medicated schizophrenic patients compared to normal controls.
  • To examine whether abnormalities in N400 amplitude or latency are present in schizophrenia and what they signify.

Main Methods:

  • A semantic categorization task involving word pairs was administered to schizophrenic patients and healthy controls.
  • Event-related potentials (ERPs), specifically the N400 component, were recorded and analyzed.

Related Experiment Videos

Main Results:

  • The N400 component was found to be reduced and delayed in schizophrenic patients compared to controls.
  • Analysis of individual data revealed that N400 abnormalities were present only in a subgroup of schizophrenic patients.
  • Reduced N400 amplitude suggests impaired semantic expectancies, while delayed N400 latency indicates a delay in information processing.

Conclusions:

  • Medicated schizophrenic patients exhibit altered N400 processing, suggesting underlying semantic and information processing deficits.
  • These findings highlight the heterogeneity of cognitive impairments in schizophrenia, with specific subgroups showing distinct electrophysiological abnormalities.
  • The N400 component serves as a valuable tool for understanding the neurobiological underpinnings of cognitive dysfunction in schizophrenia.