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Related Experiment Video

Updated: Jun 15, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

Thyroid nodule with eggshell calcification and oncocytic thyroid cancer.

Subhashini Yaturu¹, Laura Rainer

¹Section of Endocrinology, Shreveport, LA, USA. subhashini.yaturu@med.va.gov

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

|March 2, 2010

Summary

This case report highlights a rare instance of Hurthle cell thyroid cancer presenting with eggshell calcification. This finding underscores that extensive calcification does not rule out malignancy in thyroid nodules.

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Area of Science:

Endocrinology
Oncology
Radiology

Background:

Reporting a rare case of Hurthle cell carcinoma of the thyroid.
Focusing on unusual eggshell calcification within the tumor.
Discussing diagnostic and therapeutic strategies for this rare presentation.

Observation:

A 62-year-old man presented with an asymptomatic thyroid nodule.
Ultrasound revealed a large, heterogeneous mass with coarse, peripheral calcifications.
Fine-needle aspiration (FNA) showed numerous Hurthle cells with atypical features.

Findings:

Post-thyroidectomy, a large encapsulated Hurthle cell carcinoma was identified.
The tumor exhibited pericapsular and vascular invasion.
Extensive, thick calcification required decalcification for histological sectioning.

Implications:

This case demonstrates that eggshell calcification can occur in thyroid cancer.
Highlights the importance of comprehensive evaluation despite calcification.
Suggests that advanced imaging and histological analysis are crucial for accurate diagnosis.