Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a significant...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes and Comparisons of Minimally Invasive Distal Metatarsal and Phalangeal Osteotomies With Traditional Open Osteotomies for Hallux Valgus Deformity.

Journal of the American Podiatric Medical Association·2025
Same author

Key advances in the development of reversible covalent inhibitors.

Future medicinal chemistry·2025
Same author

Ultrasound Induces Similar Temporal Endothelial Expression Patterns of eNOS and KLF2 as Normal Flow.

Ultrasound in medicine & biology·2024
Same author

Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.

Journal of medicinal chemistry·2024
Same author

Discovery of TRPA1 Antagonist <b>GDC-6599</b>: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

Journal of medicinal chemistry·2024
Same author

Crystal structure of bis(3,5-dichloro-2-hydroxybenzyl)(2-methoxyethyl)amine.

Acta crystallographica. Section E, Crystallographic communications·2023
Same journal

Decoding the Toxicity of Synthetic Cannabinoids: From Receptor Activation to Multiorgan Dysfunction.

Medicinal research reviews·2026
Same journal

AI-Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery.

Medicinal research reviews·2026
Same journal

Advances in Structural Diversity, Pharmacological Activities, and Drug Development of β-Carboline Alkaloids.

Medicinal research reviews·2026
Same journal

Small-Molecule Kinase Inhibitors Modulating Circadian Rhythms.

Medicinal research reviews·2026
Same journal

Phosphonates as Modulators of Brain Chemistry.

Medicinal research reviews·2026
Same journal

A Comprehensive Insight of Mechanisms of Drugs Targeting Ion Channels: Exemplified by Marine Natural Products and Their Analogues.

Medicinal research reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
09:05

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

Published on: August 20, 2016

Selective MMP13 inhibitors.

Jie Jack Li1, Adam R Johnson

  • 1Discovery Chemistry, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA. jack.li@bms.com

Medicinal Research Reviews
|March 3, 2010
PubMed
Summary
This summary is machine-generated.

This review covers the pharmacology of matrix metalloproteinase 13 (MMP13) and its selective inhibitors. Understanding MMP13 is key for developing targeted therapies for diseases involving this enzyme.

Related Experiment Videos

Last Updated: Jun 15, 2026

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition
09:05

In Vitro and In Vivo Models to Study Corneal Endothelial-mesenchymal Transition

Published on: August 20, 2016

Area of Science:

  • Biochemistry
  • Pharmacology
  • Enzymology

Background:

  • Matrix metalloproteinase 13 (MMP13) is a key enzyme implicated in extracellular matrix degradation.
  • Dysregulation of MMP13 activity is associated with various pathological conditions, including arthritis and cancer.
  • Targeting MMP13 offers a potential therapeutic strategy for diseases characterized by excessive tissue remodeling.

Purpose of the Study:

  • To review the current understanding of matrix metalloproteinase 13 (MMP13) pharmacology.
  • To discuss the development and characteristics of selective MMP13 inhibitors.
  • To highlight the therapeutic potential of MMP13 inhibition.

Main Methods:

  • Literature review of peer-reviewed scientific articles.
  • Analysis of pharmacological data related to MMP13.
  • Synthesis of information on selective MMP13 inhibitor development.

Main Results:

  • Detailed overview of MMP13 structure, function, and regulation.
  • Discussion of various classes of MMP13 selective inhibitors.
  • Evaluation of preclinical and clinical data for MMP13 inhibitors.

Conclusions:

  • MMP13 remains a significant target for therapeutic intervention.
  • Selective MMP13 inhibitors show promise but require further investigation.
  • Continued research is essential for optimizing MMP13-targeted therapies.