Related Experiment Video
Updated: Jun 15, 2026
07:57
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
Published on: March 24, 2022
RADAR realistic animal model series for dose assessment
Mary A Keenan1, Michael G Stabin, William P Segars
1Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA. mary.a.emmons@vanderbilt.edu
Summary
Realistic digital mouse (MOBY) and rat (ROBY) phantoms were developed for accurate radiopharmaceutical dose calculations in rodent models. These models improve understanding of radiation toxicity and treatment efficacy in preclinical studies.
Area of Science:
- Nuclear Medicine and Medical Physics
- Preclinical Radiation Dosimetry
- Biophysical Modeling
Background:
- Rodent models are crucial for radiopharmaceutical testing and approval.
- Accurate internal dose estimation in animal models is vital for assessing radiation toxicity and treatment efficacy.
- Previous dose estimation relied on simplified mathematical models.
Purpose of the Study:
- To develop anatomically realistic digital phantoms for mice (MOBY) and rats (ROBY).
- To facilitate accurate internal dose calculations in rodent models using these phantoms.
- To improve the reliability of preclinical radiopharmaceutical research.
Main Methods:
- Developed MOBY and ROBY phantoms using nonuniform rational B-spline (NURBS) technology.
- Utilized voxel-based phantom versions with radiation transport codes.
- Calculated specific absorbed fractions (SAFs) for internal photon and electron sources in relevant organs.
Main Results:
- Calculated photon and electron SAFs for various organs in MOBY and ROBY models.
- Compared SAF results with existing literature data.
- Developed dose factors for radiation dose calculations using standardized decay data.
Conclusions:
- Organ masses in MOBY and ROBY phantoms show reasonable agreement with other models, though variations exist.
- Electron absorbed fractions for organ self-irradiation were <1.0 at energies >0.5 MeV.
- Measurable cross-irradiation was observed for high-energy electrons between organ pairs.
