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Chemically ubiquitylated PCNA as a probe for eukaryotic translesion DNA synthesis

Junjun Chen1, Yongxing Ai, Jialiang Wang

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.

Nature Chemical Biology
|March 9, 2010
PubMed

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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...