Related Experiment Video
Updated: Jun 15, 2026

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
GD1a-associated pure motor Guillain-Barré syndrome with hyperreflexia and bilateral papillitis
Christoph Neuwirth1, Daniel Mojon, Markus Weber
1Neuromuscular Diseases Unit, Kantonsspital St. Gallen, St. Gallen, Switzerland. Christoph.neuwirth@kssg.ch
Abstract:
A patient with acute purely motor polyneuropathy with positive GD1a ganglioside antibodies who presented with paresis in combination with hyperreflexia is reported. Neurophysiological tests revealed features compatible with acute motor axonal neuropathy. Therapy with intravenous immunoglobulin led to rapid clinical improvement. However, at the time when signs of active denervation appeared on electromyographic testing, the patient developed bilateral papillitis. The pathogenesis of pure motor Guillain-Barré syndrome with hyperreflexia and papillitis is discussed.
Related Concept Videos
Myasthenia Gravis ll: Pathophysiology
Botulism
Myasthenia Gravis: Diagnostic Tests
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Poliomyelitis
Myasthenia Gravis: Overview and Treatment
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Multiple Sclerosis l: Introduction
