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Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

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Updated: Jun 15, 2026

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5
10:49

Murine Neural Plate Targeting by In Utero Nano-Injection (NEPTUNE) at Embryonic Day 7.5

Published on: February 14, 2022

Needle-free vaccine injection.

Mark A F Kendall1

  • 1Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Building 75-Cnr of College and Cooper Road The University of Queensland Brisbane, Brisbane, QLD4072, Australia. m.kendall@uq.edu.au

Handbook of Experimental Pharmacology
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Developing needle-free vaccine delivery methods is crucial for infectious disease prevention. This research explores physical delivery systems, like biolistic particle delivery, for enhanced vaccine targeting to skin and mucosal sites.

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Area of Science:

  • Biomedical Engineering
  • Immunology
  • Vaccinology

Background:

  • Infectious diseases cause millions of deaths annually.
  • Current vaccine delivery methods struggle to target optimal immunological sites like skin and mucosa.
  • Needle-free delivery systems offer potential advantages for vaccine administration.

Purpose of the Study:

  • To investigate physical, needle-free approaches for vaccine delivery.
  • To analyze the challenges and requirements for targeting skin and mucosal layers.
  • To review current physical cell targeting technologies and focus on biolistic particle delivery.

Main Methods:

  • Review of skin's structural and immunogenic properties.
  • Examination of needle-free delivery technologies: diffusion patches, jet injectors, microneedles.
  • Analysis of biolistic particle delivery systems, including device engineering and skin interaction.
  • Evaluation of mechanical impact, cell death, and clinical outcomes of DNA vaccines delivered via engineered devices.

Main Results:

  • Skin and mucosal sites offer immunological, physical, and practical advantages for vaccination.
  • Biolistic particle delivery systems require specific engineering for clinical needs.
  • Understanding the mechanical interactions of ballistic impact and cellular responses is key.
  • DNA vaccines delivered via engineered devices show clinical outcomes.

Conclusions:

  • Effective needle-free vaccine delivery to skin and mucosal sites remains a challenge.
  • Biolistic particle delivery presents a promising avenue for targeted vaccine administration.
  • Further research into device engineering and biological interactions is needed to optimize vaccine delivery.